Study: People worldwide living longer, but sicker

LONDON (AP) — Nearly everywhere around the world, people are living longer and fewer children are dying. But increasingly, people are grappling with the diseases and disabilities of modern life, according to the most expansive global look so far at life expectancy and the biggest health threats.

The last comprehensive study was in 1990 and the top health problem then was the death of children under 5 — more than 10 million each year. Since then, campaigns to vaccinate kids against diseases like polio and measles have reduced the number of children dying to about 7 million.

Malnutrition was once the main health threat for children. Now, everywhere except Africa, they are much more likely to overeat than to starve.

With more children surviving, chronic illnesses and disabilities that strike later in life are taking a bigger toll, the research said. High blood pressure has become the leading health risk worldwide, followed by smoking and alcohol.

"The biggest contributor to the global health burden isn't premature (deaths), but chronic diseases, injuries, mental health conditions and all the bone and joint diseases," said one of the study leaders, Christopher Murray, director of the Institute of Health Metrics and Evaluation at the University of Washington.

In developed countries, such conditions now account for more than half of the health problems, fueled by an aging population. While life expectancy is climbing nearly everywhere, so too are the number of years people will live with things like vision or hearing loss and mental health issues like depression.

The research appears in seven papers published online Thursday by the journal Lancet. More than 480 researchers in 50 countries gathered data up to 2010 from surveys, censuses and past studies. They used statistical modeling to fill in the gaps for countries with little information. The series was mainly paid for by the Bill & Melinda Gates Foundation.

As in 1990, Japan topped the life expectancy list in 2010, with 79 for men and 86 for women. In the U.S. that year, life expectancy for men was 76 and for women, 81.

The research found wide variations in what's killing people around the world. Some of the most striking findings highlighted by the researchers: — Homicide is the No. 3 killer of men in Latin America; it ranks 20th worldwide. In the U.S., it is the 21st cause of death in men, and in Western Europe, 57th.

— While suicide ranks globally as the 21st leading killer, it is as high as the ninth top cause of death in women across Asia's "suicide belt," from India to China. Suicide ranks 14th in North America and 15th in Western Europe.

— In people aged 15-49, diabetes is a bigger killer in Africa than in Western Europe (8.8 deaths versus 1 death per 100,000).

— Central and Southeast Asia have the highest rates of fatal stroke in young adults at about 15 cases per 100,000 deaths. In North America, the rate is about 3 per 100,000.

Globally, heart disease and stroke remain the top killers. Reflecting an older population, lung cancer moved to the 5th cause of death globally, while other cancers including those of the liver, stomach and colon are also in the top 20. AIDS jumped from the 35th cause of death in 1990 to the sixth leading cause two decades later.

While chronic diseases are killing more people nearly everywhere, the overall trend is the opposite in Africa, where illnesses like AIDS, malaria and tuberculosis are still major threats. And experts warn again shifting too much of the focus away from those ailments.

"It's the nature of infectious disease epidemics that if you turn away from them, they will crop right back up," said Jennifer Cohn, a medical coordinator at Doctors Without Borders.

Still, she acknowledged the need to address the surge of other health problems across Africa. Cohn said the agency was considering ways to treat things like heart disease and diabetes. "The way we treat HIV could be a good model for chronic care," she said.

Others said more concrete information is needed before making any big changes to public health policies.

"We have to take this data with some grains of salt," said Sandy Cairncross, an epidemiologist at the London School of Hygiene and Tropical Medicine.

He said the information in some of the Lancet research was too thin and didn't fully consider all the relevant health risk factors.

"We're getting a better picture, but it's still incomplete," he said.

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Why Rice took her name off the list

Ambassador Susan Rice stunned Washington Thursday afternoon by withdrawing her name for consideration as secretary of State. President Obama accepted her decision.

Currently the US envoy to the United Nations, Ambassador Rice was widely seen as a top prospect to replace Secretary of State Hillary Rodham Clinton, who is retiring at the end of Mr. Obama’s first term. But her star was tarnished in September after she made erroneous statements on TV about the attack on the US consulate in Benghazi, Libya, which took the lives of four Americans, including Ambassador Christopher Stevens.

High-profile Republicans, including Sen. John McCain of Arizona, had promised a major fight if Obama had sent her name to the Senate for confirmation. By accepting her withdrawal, Obama has avoided expending political capital in trying to get her through the Senate, and also avoided refocusing the national spotlight on what went wrong in Benghazi.

RECOMMENDED: Five ways events overseas could shape Obama's second term

“If nominated, I am now convinced that the confirmation process would be lengthy, disruptive, and costly – to you and to our most pressing national and international priorities,” Rice wrote in a letter to Obama and obtained by NBC News. “That trade-off is simply not worth it to our country…. Therefore, I respectfully request that you no longer consider my candidacy at this time.”

The White House released a statement from the president indicating that he had spoken with Rice, and accepted her request to remove her name from consideration. He lauded her service as “an extraordinarily capable, patriotic, and passionate public servant.”

“While I deeply regret the unfair and misleading attacks on Susan Rice in recent weeks, her decision demonstrates the strength of her character, and an admirable commitment to rise above the politics of the moment to put our national interests first,” the president’s statement said.

At issue were her statements over what had precipitated the attack on the US mission in Benghazi. In a round of Sunday morning TV interviews five days after the Sept. 11 incident, she said it had resulted from spontaneous protests over an anti-Islamic video and was not a coordinated terrorist attack, possibly linked to Al Qaeda affiliates.

In late November, Rice acknowledged that her initial explanation was partially inaccurate, but that did not mollify her critics. She met on Capitol Hill with Senator McCain and Sens. Lindsey Graham (R) of South Carolina and Kelly Ayotte (R) of New Hampshire, but they did not back down in their opposition to her potential nomination as secretary of State.

McCain slammed the handling of Benghazi as either a coverup or incompetence. Fox News also kept up the drumbeat of pressure with in-depth coverage. The suggestion was that the Obama administration did not want to acknowledge a successful terrorist attack – one that led to the first killing of a US ambassador since 1979 – at the height of the presidential campaign.

In his statement, Obama indicated that Rice will remain as UN ambassador, and lauded her service.

“Already, she has secured international support for sanctions against Iran and North Korea, worked to protect the people of Libya, helped achieve an independent South Sudan, stood up for Israel’s security and legitimacy, and served as an advocate for UN reform and the human rights of all people,” Obama said.

“I am grateful that Susan will continue to serve as our ambassador at the United Nations and a key member of my cabinet and national security team, carrying her work forward on all of these and other issues.”

Now all eyes turn to Sen. John Kerry (D) of Massachusetts, another top prospect for secretary of State. Senator Kerry is an experienced foreign-policy hand, and has long been thought to want the job. But having him leave the Senate could cost the Democrats his seat.

Massachusetts’s other senator, Scott Brown (R), just lost reelection to Democratic firebrand Elizabeth Warren. But he remains popular in the Bay State and would be a strong candidate in a special election to replace Kerry. The Democrats don’t have an obvious choice – unless Gov. Deval Patrick (D) were to jump in.

Obama also must soon decide his nominee for another about-to-be-vacant post: secretary of Defense. News reports Thursday indicated that former US Sen. Chuck Hagel of Nebraska, a Republican, may have the edge to replace Leon Panetta, who has made clear his intention to step down.

RECOMMENDED: Five ways events overseas could shape Obama's second term

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Official: Syria fires Scud missiles at rebels

KABUL, Afghanistan (AP) — Syrian government forces have fired Scud missiles at insurgents in recent days, escalating the 2-year-old conflict against rebels seeking to overthrow the regime, U.S. officials said Wednesday.

Speaking on condition of anonymity, two officials said forces of President Bashar Assad have fired the missiles from the Damascus area into northern Syria. These officials asked not to be named because they weren't authorized to discuss the matter publicly.

News of the missiles came on the same day that more than 100 countries, including the United States, recognized a new Syrian opposition coalition. That has further isolated Assad's regime and opened a way for greater humanitarian assistance to the forces battling to oust him.

One official said there was no indication that chemical weapons were aboard the missiles. Officials have said over the past week that they feared rebel advances were prompting Assad to consider using chemical weapons.

This official estimated that the number of Scuds fired was more than a half dozen, confirming details first reported by The New York Times.

State Department spokeswoman Victoria Nuland said Assad has fired missiles, but wouldn't specify what kind.

"As the regime becomes more and more desperate, we see it resorting to increased lethality and more vicious weapons moving forward and we have in recent days seen missiles deployed," she said.

White House press secretary Jay Carney, speaking to reporters, said he could not confirm the report, but said if true it would be a sign of desperation.

"The idea that the Syrian regime would launch missiles, within its borders, at its own people, is stunning, desperate and a completely disproportionate military escalation," Carney said.

The new development happened as officials planned an international conference to further assist opposition to Assad.

"This is the usual pattern of behavior that whenever there is an important decision that is anti-Assad taken by the international community, the Assad regime escalates the degree of violence to show its degree of displeasure," said Murhaf Jouejati, a specialist on Syrian affairs at the National Defense University. "Like saying, 'Oh, yeah? I'll show you!' "

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Associated Press writers Julie Pace, Matthew Lee, Pauline Jelinek and Kimberly Dozier contributed to this report from Washington.

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Music royalty rocks NYC in Sandy benefit concert

NEW YORK (AP) — New Jersey shore hero Bruce Springsteen opened a benefit concert for victims of Superstorm Sandy on Wednesday by making a plea that what made his boyhood home special not be forgotten when it is rebuilt.

Music royalty from the Rolling Stones to Kanye West, including several artists with direct ties to the New York metropolitan area, gathered at Madison Square Garden for a concert being televised, streamed online and aired on radio all over the world.

Springsteen and his E Street Band began the show with a roar, singing "Land of Hope and Dreams" and "Wrecking Ball." He addressed the rebuilding process before his song "My City of Ruins." He noted that the song was written about the hard times suffered by Asbury Park, N.J., before a renaissance over the past decade.

He lauded the Jersey shore as an inclusive area, where the rich and the poor can find a place.

"I pray that that characteristic remains along the Jersey shore because that's what makes it special," Springsteen said.

He mixed "My City of Ruins" with part of Tom Waits' "Jersey Girl" before bringing neighbor Jon Bon Jovi out to sing "Born to Run" with him.

Comic Billy Crystal got an immediate laugh by taking a shot at a Long Island lighting company that drew criticism for the slow pace of power restoration after the storm hit the area on Oct. 29.

Roger Waters played a set of Pink Floyd's spacey rock, joined by Eddie Vedder for "Comfortably Numb." Waters stuck to the music and left the fundraising to others.

"Can't chat," he said, "because we only have 30 minutes."

The sold-out "12-12-12" concert was being shown on 37 television stations in the United States and more than 200 others worldwide. It was to be streamed on 30 websites, including YouTube and Yahoo, and played on radio stations. Theaters, including 27 in the New York region and dozens more elsewhere, were showing it live. More than 2 billion people were expected to have access to the performance.

Proceeds from the show will be distributed through the Robin Hood Foundation. More than $30 million was raised through ticket sales alone.

The powerful storm left parts of New York City underwater and left millions of people in several states without heat or electricity for weeks. It's blamed for at least 125 deaths, including 104 in New York and New Jersey, and it destroyed or damaged 305,000 housing units in New York alone.

Other concert performers were to include Long Islander Billy Joel ("New York State of Mind") and New Yorker Alicia Keys ("Empire State of Mind"). Even Liverpool's Paul McCartney has a New York office, Hamptons home and a wife, Nancy Shevell, who spent a decade on the board of the agency that runs New York's public transit system.

The Rolling Stones' Mick Jagger said he wasn't in New York for the storm but his apartment was flooded with 2 feet of water.

"Imagine you hadn't known it was coming," he said in an interview. "It would have been pretty dire. I think it's good to do events to support people in the area where you're very familiar with. I mean, I've been coming here for a long time."

Other artists expected to perform included Eric Clapton, Dave Grohl, Chris Martin and The Who.

It's a lineup heavily weighted toward classic rock, which has the type of fans able to afford a show for which ticket prices ranged from $150 to $2,500. Even with those prices, people with tickets have been offering them for more on broker sites such as StubHub, an attempt at profiteering that producers fumed was "despicable."

The concert came a day after the death of sitar master Ravi Shankar, a performer at the 1971 "Concert for Bangladesh" considered the grandfather of music benefits. That also was in Madison Square Garden.

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AP Music Writer Mesfin Fekadu in New York contributed to this report.

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Congress examines science behind HGH test for NFL

WASHINGTON (AP) — A congressional committee has opened a hearing to examine the science behind a human growth hormone test the NFL wants to start using on its players.

Nearly two full seasons have passed since the league and the players' union signed a labor deal that set the stage for HGH testing.

The NFL Players Association won't concede the validity of a test that's used by Olympic sports and Major League Baseball, and the sides haven't been able to agree on a scientist to help resolve that impasse.

Among the witnesses before the House Oversight and Government Reform Committee on Wednesday is Pro Football Hall of Fame member Dick Butkus. In his prepared statement, Butkus writes: "Now, let's get on with it. The HGH testing process is proven to be reliable."

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Public's response saved lives in rampage

Citizens' coolheadedness and individual preparation for coping with gunfire in public settings may have curtailed the casualty count from Tuesday's shooting at a Portland, Ore., shopping mall, law officers suggested on the day after the tragedy.

Two people died and one was critically wounded before the shooter, 22-year-old Jacob Tyler Roberts of Portland, killed himself a few minutes after running into the food court at the Clackamas Town Center mall. Officials say Mr. Roberts, wearing camouflage and a white hockey mask, had methodically fired "multiple" rounds from an assault-style rifle at random shoppers.

Most of the 10,000 Christmas shoppers at the mall appeared nearly as ready and able as police to deal with a gunman appearing suddenly in their midst, Clackamas County Sheriff Craig Roberts said on Wednesday.

"Many people have asked me why there were so few victims during this incident," said Sheriff Roberts. He listed the fact that Mr. Roberts's AR-15 semiautomatic rifle intermittently jammed and noted a well-practiced mall lockdown procedure. But he also credited "10,000 people in the mall who at one time kept a level head, got themselves out of the mall, helped others get out, secured themselves in stores.… It was really about a whole group of people coming together to make a difference."

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Law officers said during a Wednesday press conference that they did not know whether any member of the public carrying a concealed weapon had counterattacked Roberts. But they said they are certain that Roberts died by his own hand after fleeing down a stairwell from the mall's upper level.

The death rate from mass shootings has ticked up slightly in recent years, even as deaths in single-victim incidents have decreased, according to a recent analysis of FBI crime data by the Huffington Post. The worst recent mass shooting came in July in Aurora, Colo., where a gunman killed 12 people and injured 58 during a midnight screening of a new "Batman" movie.

Gun-control advocates seized on the mall shooting as a possible result of the expiration in 2004 of a national ban on assault weapons.

"Santa Claus could have been shot in the mall," said Penny Okamoto, executive director of Ceasefire Oregon, in an interview with the Portland Tribune. "If you're sick of this, you should call your legislators to tell them to fix the laws so that assault weapons don't end up in the hands of felons."

Many versions of the AR-15 were banned under the assault weapons law, but it's not known if the gun used in the Clackamas mall shooting was one of them.

Police said Roberts had no criminal record and had stolen the AR-15 from "someone he knew."

Does the collected response by shoppers at the Clackamas Town Center indicate that Americans are becoming less daunted by senseless violence and, perhaps, better ready to react? Those who back broad gun rights under the Constitution's Second Amendment suggest a shift may be under way in people's readiness to respond.

In blocking Illinois's ban on concealed weapons, the last such law in the nation, Seventh US Circuit Court of Appeals Judge Richard Posner on Tuesday implied that self-defense readiness in public is not only protected by the US Constitution, but may be good social policy. An awareness "that many law-abiding citizens are walking the streets armed may make criminals timid," he wrote in his ruling.

"As far as a social shift, I think people are getting more intelligent and appropriate in their reactions to shooters," says Dave Kopel, research director at the Independence Institute, a libertarian-leaning think tank in Golden, Colo. "Police training has changed in significant ways since the Columbine [High School] shooting [in 1999], where they no longer wait for the SWAT team to arrive but go in immediately with … the army they have. There's also an awareness [among police and the public] that if you're trying to stop a gangster from robbing a liquor store, you may have a [heck] of a fight on your hands, but that these publicity-seeking guys with mental illness, they basically crumble at first opposition."

The upshot, says Mr. Kopel: "Lying down and cowering doesn't seem to work very well, so law enforcement has gotten smarter and civilians have gotten smarter."

In Clackamas County, Sheriff Roberts said local law-enforcement personnel had trained earlier this year for a shooting scenario at Clackamas Town Center, an exercise that involved both police and retailers. On Tuesday, arriving police, in keeping with evolving police tactics nationwide, formed small teams and quickly entered the mall to pursue the shooter. Police could not say Wednesday whether any officers saw the shooter before he killed himself.

Dennis Curtis, the mall's general manager, noted that police officers told him that they were amazed "how many stores were secured and people were locked in place" upon entering the mall to look for the shooter.

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SKorea says NKorea has fired its long-range rocket

SEOUL, South Korea (AP) — North Korea fired a long-range rocket Wednesday in its second launch under its new leader, South Korean officials said, defying warnings from the U.N. and Washington only days before South Korean presidential elections.

South Korean defense officials said the rocket was fired from a west coast launch pad but there was no immediate word if the rocket was successful. North Korea had indicated technical problems with the rocket and extended its launch window. The officials spoke on condition of anonymity, citing office rules.

North Korea's Kim Jong Un took power after his father Kim Jong Il died on Dec. 17 last year, and the launch also comes about a month before President Barack Obama is inaugurated for his second term.

The North says the Unha rocket is meant to put a satellite in orbit. A similar launch in April broke apart shortly after liftoff, and the condemnation that attempt received is likely to be repeated. Washington sees the launch as a cover for a test of technology for missiles that could be used to strike the United States.

Rocket tests are seen as crucial to advancing North Korea's nuclear weapons ambitions. North Korea is thought to have only a handful of rudimentary nuclear bombs. But Pyongyang is not yet believed capable of building warheads small enough to mount on a missile that could threaten the United States.

North Korea has spent decades trying to perfect a multistage, long-range rocket. Experts say that ballistic missiles and rockets in satellite launches share similar bodies, engines and other technology. This is the fifth attempt at a long-range launch since 1998, when Pyongyang sent a rocket hurtling over Japan. Previous launches of three-stage rockets weren't considered successful.

Washington sees North Korea's pursuit of nuclear weapons and ballistic missiles as a threat to world security and to its Asian allies, Japan and South Korea.

North Korea under new leader Kim has pledged to bolster its nuclear arsenal unless Washington scraps what Pyongyang calls a hostile policy.

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California PUC Finalizing Free Cell Phone Service for the Poor

As noted by KGO, the California Public Utilities Commission (CPUC) intends to approve a free lifeline cell phone plan that benefits California‘s poor and homeless residents. Funding for initial setup will come from the federal government.

What are the initial details of the plan?

Qualifying Californians pay an initial $ 20 fee to sign up for a monthly cell coverage plan. It offers 250 free minutes as well as 250 free text messages. From then on, the minutes and message count refill every month as long as the participant qualifies for the program. Assured Wireless — the name of the plan devised by Virgin Mobile, KERN Radio notes — has proposed this coverage to the CPUC.

Unlike the landline lifeline service, which only reduces a phone bill, this cell phone service is actually free of charge for participants. The company notes that plan participants can pay extra for international calling and for the purchase of additional minutes. The phone is free and network service is provided by Sprint. It is not known at this time if paying cell phone service customers will be charged a surcharge or fee to fund the program.

Who benefits from the free cell phone service?

The Coalition on Homelessness notes that those living on the streets will see an immediate benefit. “It’s so huge if you’re living outside you can dial 9-1-1 in the middle of the night; if you need to get in touch with your loved ones, you have a phone, if you’re trying to get in touch with a potential employer,” the Coalition on Homelessness’ Jennifer Friedenbach explained. Low-income wage earners, too, benefit since they no longer have to take money from other budget line items to afford a cell phone.

What is the wage income maximum for a qualifying program participant?

Participants cannot earn more than about $ 15,000 per year to qualify for the free cell phone program.

Is this type of program new?

This is not a new program. There are already 36 states that offer cell phone lifeline programs. The California PUC has thus far been unwilling to approve the program for the State of California.

Why does California need free cell phone service in the first place?

Although the State of California does participate in the federal lifeline landline service via local phone service providers, the number of landlines in service has decreased by 43 percent since 2000. On the flipside, the number of cell phones in use has increased by 123 percent.

What do critics say?

As noted by KERN, there is a question of taxpayer and cell phone customer cost. In other states, Sprint contributes to the program. It then has the option of charging its paying customers a fee that funds the program.

What do proponents say?

As noted by 4-Traders, Assurance Wireless has crunched the numbers for the entire nation and purports, “If all 28.5 million adults eligible for Lifeline Assistance were to take advantage of the program and earn at the same rate and level as [the study] sample, it would result in $ 3.7 billion in fresh income for the poor and near poor.”

What happens next?

As noted by the San Francisco Chronicle, the CPUC has already approved the Golden State’s participation in the program. It now needs to work out the details of Assurance Wireless’ promotional programs to advertise the free cell phone service. Program finalization is tentatively set for two weeks from now.

Sylvia Cochran is a Los Angeles area resident with a firm finger on the pulse of California politics. Talk radio junkie, community volunteer and politically independent, she scrutinizes the good and the bad from both sides of the political aisle.

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LA prosecutors seek to violate Lohan's probation

LOS ANGELES (AP) — Los Angeles prosecutors on Tuesday asked a judge to revoke Lindsay Lohan's probation and schedule a hearing that could lead to the actress' return to jail.

The filing came one day before Lohan is scheduled to be arraigned Wednesday on three misdemeanor charges filed last month related to a June car crash.

Lohan will not need to be present for Wednesday's arraignment on charges she lied to Santa Monica police, was driving recklessly and obstructed an officer from performing duties related to the crash investigation. She remains on probation for a 2011 necklace theft case and could be sentenced to 245 days in jail if a judge determines her conduct was a probation violation.

Her attorney Shawn Holley did not immediately return an email seeking comment.

City attorney's spokesman Frank Mateljan said any probation violation proceedings are likely to be heard after the Santa Monica case. Prosecutors allege Lohan lied about being a passenger in her Porsche when it crashed on Pacific Coast Highway on the way to a film shoot.

The "Liz and Dick" star was released from supervised probation in March after completing several months of court appearances and morgue cleanup duty.

Lohan has yet to be booked on the new charges and a judge on Wednesday will likely set bail and the terms of her release.

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DA investigating Texas' troubled $3B cancer agency

AUSTIN, Texas (AP) — Turmoil surrounding an unprecedented $3 billion cancer-fighting effort in Texas worsened Tuesday when its executive director offered his resignation and the state's chief public corruption prosecutor announced an investigation into the beleaguered agency.

No specific criminal allegations are driving the latest probe into the Cancer Prevention and Research Institute of Texas, said Gregg Cox, director of the Travis County district attorney's public integrity unit. But his influential office opened a case only weeks after the embattled agency disclosed that an $11 million grant to a private company bypassed review.

That award is the latest trouble in a tumultuous year for CPRIT, which controls the nation's second-largest pot of cancer research dollars. Amid the mounting problems, the agency announced Tuesday that Executive Director Bill Gimson had submitted his letter of resignation.

"Unfortunately, I have also been placed in a situation where I feel I can no longer be effective," Gimson wrote in a letter dated Monday.

Gimson said the troubles have resulted in "wasted efforts expended in low value activities" at the agency, instead of a focused fight against cancer. Gimson offered to stay on until January, and the agency's board must still approve his request to step down.

His departure would complete a remarkable house-cleaning at CPRIT in a span of just eight months. It began in May, when Dr. Alfred Gilman resigned as chief science officer in protest over a different grant that the Nobel laureate wanted approved by a panel of scientists. He warned it would be "the bomb that destroys CPRIT."

Gilman was followed by Chief Commercialization Officer Jerry Cobbs, whose resignation in November came after an internal audit showed Cobbs included an $11 million proposal in a funding slate without a required outside review of the project's merits. The lucrative grant was given to Dallas-based Peloton Therapeutics, a biomedical startup.

Gimson chalked up Peloton's award to an honest mistake and has said that, to his knowledge, no one associated with CPRIT stood to benefit financially from the company receiving the taxpayer funds. That hasn't satisfied some members of the agency's governing board, who called last week for more assurances that no one personally profited.

Cox said he has been following the agency's problems and his office received a number of concerned phone calls. His department in Austin is charged with prosecuting crimes related to government officials; his most famous cases include winning a conviction against former U.S. House Majority Leader Tom DeLay in 2010 on money laundering charges.

"We have to gather the facts and figure what, if any, crime occurred so that (the investigation) can be focused more," Cox said.

Gimson's resignation letter was dated the same day the Texas attorney general's office also announced its investigation of the agency. Cox said his department would work cooperatively with state investigators, but he made clear the probes would be separate.

Peloton's award marks the second time this year that a lucrative taxpayer-funded grant authorized by CPRIT instigated backlash and raised questions about oversight. The first involved the $20 million grant to M.D. Anderson Cancer Center in Houston that Gilman described as a thin proposal that should have first been scrutinized by an outside panel of scientific peer-reviewers, even though none was required under the agency's rules.

Dozens of the nation's top scientists agreed. They resigned en masse from the agency's peer-review panels along with Gilman. Some accused the agency of "hucksterism" and charting a politically-driven path that was putting commercial product-development above science.

The latest shake-up at CPRIT caught Gilman's successor off-guard. Dr. Margaret Kripke, who was introduced to reporters Tuesday, acknowledged that she wasn't even sure who she would be answering to now that Gimson was stepping down. She said that although she wasn't with the agency when her predecessor announced his resignation, she was aware of the concerns and allegations.

"I don't think people would resign frivolously, so there must be some substance to those concerns," Kripke said.

Kripke also acknowledged the challenge of restocking the peer-review panels after the agency's credibility was so publicly smeared by some of the country's top scientists. She said she took the job because she felt the agency's mission and potential was too important to lose.

Only the National Institutes of Health doles out more cancer research dollars than CPRIT, which has awarded more than $700 million so far.

Gov. Rick Perry told reporters in Houston on Tuesday that he wasn't previously aware of the resignation but said Gimson's decision to step down was his own.

Joining the mounting criticism of CPRIT is the woman credited with brainstorming the idea for the agency in the first place. Cathy Bonner, who served under former Texas Gov. Ann Richards, teamed with cancer survivor Lance Armstrong in selling Texas voters in 2007 on a constitutional amendment to create an unprecedented state-run effort to finance a war on disease.

Now Bonner says politics have sullied an agency that she said was built to fund research, not subsidize private companies.

"There appears to be a cover-up going on," Bonner said.

Peloton has declined comment about its award and has referred questions to CPRIT. The agency has said the company wasn't aware that its application was never scrutinized by an outside panel, as required under agency rules.

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